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Figure 2 2.1 The primary factor contributing to the deterioration in oocyte quality is the elevation in oxidative stress In women of advanced reproductive age, oocytes demonstrate elevated levels of reactive ROS as a consequence of mitochondrial dysfunction

Eussen SJ, de Groot LC, Clarke R, Schneede J, Ueland PM, Hoefnagels WH, et al: Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial